前列腺素信号通过前列腺素受体
中文名称
通路描述
前列腺素（PGI2）由健康的血管内皮细胞持续产生。它通过与Gs耦合受体PTGIR相互作用抑制血小板激活，导致cAMP增加，进而增加cAMP依赖性蛋白激酶活性，从而防止细胞内[Ca2+]增加，这是血小板激活所必需的（Woulfe et al. 2001）。PGI2也是一种有效的血管扩张剂。这些效应与血栓素（TXA2），另一种二十烷酸，的效应相反，形成血液循环和血小板激活的平衡。
英文描述
Prostacyclin signalling through prostacyclin receptor Prostacyclin (PGI2) is continuously produced by healthy vascular endothelial cells. It inhibits platelet activation through interaction with the Gs-coupled receptor PTGIR, leading to increased cAMP, a consequent increase in cAMP-dependent protein kinase activity which prevents increases of cytoplasmic [Ca2+] necessary for activation (Woulfe et al. 2001). PGI2 is also an effective vasodilator. These effects oppose the effects of thromboxane (TXA2), another eicosanoid, creating a balance of blood circulation and platelet activation.
所含基因
20 个基因