Ephrin信号
中文名称
通路描述
Ephrin（EFN）配体和EPH受体之间的相互作用不仅通过EPH受体产生前向信号，还通过EFN配体本身产生“反向”信号。EFNB通过反向信号的正确树突棘形态发生和大脑胼胝体及视网膜背侧轴突的正确路径引导是必需的。EFNBs将反向信号转导的分子机制涉及对B型Ephrins细胞内多聚酪氨酸的磷酸化，促进SH2/SH3结构域适配器蛋白GRB4的结合以及随后的细胞骨架重塑（Bruckner et al. 1997, Cowan & Henkemeyer 2001, Lu et al. 2001）。另一种反向信号机制涉及EFNBs的C末端PDZ结合基序，招募各种PDZ结构域结合蛋白。Ephrin-B1的磷酸化和PDZ依赖性反向信号已被认为在发育和疾病中的多个背景下发挥重要作用（Bush & Soriano 2009）。
英文描述
Ephrin signaling The interaction between ephrin (EFN) ligands and EPH receptors results not only in forward signaling through the EPH receptor, but also in 'reverse' signaling through the EFN ligand itself. Reverse signaling through EFNB is required for correct spine morphogenesis and proper path-finding of corpus callosum and dorsal retinal axons. The molecular mechanism by which EFNBs transduce a reverse signal involves phosphorylation of multiple, conserved tyrosines on the intracellular domain of B-type ephrins, facilitating binding of the SH2/SH3 domain adaptor protein GRB4 and subsequent cytoskeletal remodeling (Bruckner et al. 1997, Cowan & Henkemeyer 2001, Lu et al. 2001). The other mechanism of reverse signaling involves the C-terminus PSD-95/Dlg/ZO-1 (PDZ)-binding motif of EFNBs which recruits various PDZ domain containing proteins. Phosphorylation and PDZ-dependent reverse signaling by ephrin-B1 have each been proposed to play important roles in multiple contexts in development and disease (Bush & Soriano 2009).
所含基因
18 个基因