RUNX1调节雌激素受体介导的转录
中文名称
通路描述
RUNX1:CBFB复合物可通过RUNX1与ESR1的直接相互作用与激活的雌激素受体α(ESR1)结合，因此参与雌激素反应基因的转录调控，包括GPAM、KCTD6和AXIN1（Stender et al. 2010）。高GPAM表达与乳腺癌的整体生存率更好相关（Brockmoller et al. 2012）。
英文描述
CRMPs in Sema3A signaling CRMPs are a small family of plexinA-interacting cytosolic phosphoproteins identified as mediators of Sema3A signaling and neuronal differentiation. After Sema3A activation Plexin-A bound CRMP's undergo phosphorylation by Cdk5, GSK3beta and Fes kinases. Phosphorylation of CRMPs by these kinases blocks the ability of CRMP to bind to tubulin dimers, subsequently induces depolymerization of F-actin, and ultimately leads to growth cone collapse.
所含基因
16 个基因