葡萄糖依赖性胰岛素样肽（GIP）的合成、分泌和失活
中文名称
通路描述
在小肠K细胞中，转录因子PAX6和PDX-1激活编码葡萄糖依赖性胰岛素样肽（GIP，最初称为胃抑制肽）的基因。前GIP在分泌颗粒中被Prohormone Convertase 1（PC1）在2个位点切割，产生成熟的GIP。在脂肪刺激下，GIP被分泌到血液中。GIP在血液中的半衰期由二肽基肽酶IV（Dipeptidyl Peptidase IV）决定，该酶在GIP的氨基端切割2个氨基酸，使其失去生物活性。
英文描述
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) In K cells of the intestine the transcription factors PAX6 and PDX-1 activate transcription of the gene encoding Glucose-dependent Insulinotropic Polypeptide (GIP, first called Gastric Inhibitory Peptide). ProGIP is cleaved in secretory granules by Prohormone Convertase 1 (PC1) at 2 sites to yield mature GIP. In response to fat the GIP is secreted into the bloodstream. The half-life of GIP in the bloodstream is determined by Dipeptidyl Peptidase IV, which cleaves 2 amino acids at the amino terminus of GIP, rendering it biologically inactive.
所含基因
13 个基因