鞘氨醇代谢
中文名称
通路描述
鞘氨醇是一类9碳α-酮酸，通常存在于真核细胞细胞表面糖共价结合物的非还原末端。这些鞘氨醇化共价结合物在细胞识别和信号传导、神经发生、癌症转移和细菌或病毒感染中发挥重要作用。自然界中发现了超过50种鞘氨醇，其中含量最多的是N-乙酰神经氨酸（Neu5Ac，N-乙酰神经氨酸）（Li & Chen 2012, Wickramasinghe & Medrano 2011）。以下步骤描述了人类中Neu5Ac的生物合成、运输、利用和降解。
英文描述
Sialic acid metabolism Sialic acids are a family of 9 carbon alpha-keto acids that are usually present in the non reducing terminal of glycoconjuates on the cell surface of eukaryotic cells. These sialylated conjugates play important roles in cell recognition and signaling, neuronal development, cancer metastasis and bacterial or viral infection. More than 50 forms of sialic acid are found in nature, the most abundant being N-acetylneuraminic acid (Neu5Ac, N-acetylneuraminate) (Li & Chen 2012, Wickramasinghe & Medrano 2011). The steps below describe the biosynthesis, transport, utilization and degradation of Neu5Ac in humans.
所含基因
33 个基因