细胞内受体的 SUMO 酰基化
中文名称
通路描述
至少发现 17 个核受体被 SUMO 酰基化（综述：Treuter 和 Venteclef, 2011; Wadosky 等, 2012; Knutson 和 Lange, 2013）。除了少数情况（特别是 AR 和 RORA）外，SUMO 酰基化导致转录抑制。SUMO 酰基化引起的抑制被认为通过几种机制发生：干扰 DNA 结合、招募核心抑制物、在非靶标启动子处保留核心抑制物（转抑制）、核受体在细胞核内的重新定位、干扰受体的二聚化以及干扰（交叉作用）与其他翻译后修饰。受体的 SUMO 酰基化影响炎症和疾病过程（Anbalagan 等, 2012）。
英文描述
SUMOylation of intracellular receptors At least 17 nuclear receptors have been discovered to be SUMOylated (reviewed in Treuter and Venteclef 2011, Wadosky et al. 2012, Knutson and Lange 2013). In all but a few cases (notably AR and RORA) SUMOylation causes transcriptional repression. Repression by SUMOylation is believed to occur through several mechanisms: interference with DNA binding, recruitment of corepressors, retention of corepressors at non-target promoters (transrepression), re-localization of nuclear receptors within the nucleus, interference with dimerization of receptors, and interference (crosstalk) with other post-translational modifications. SUMOylation of receptors affects inflammation and disease processes (Anbalagan et al. 2012).
所含基因
28 个基因