MAPK通路的负反馈调节
中文名称
通路描述
MAPK通路的激活受到由MAPK依赖性磷酸化建立的多个负反馈环的限制。已知激活的MAPK蛋白的上游子位包括SOS、RAF1、BRAF和MAP2K1（Buday et al, 1995; Dong et al, 1996; Dougherty et al, 2005; Sturm et al, 2010; Fritsche-Guenther et al, 2011; Rushworth et al, 2006; Brummer et al, 2003; Ritt et al, 2010; Catalanotti et al, 2009）。
英文描述
Sema4D mediated inhibition of cell attachment and migration Repulsive Sema4D-Plexin-B1 signaling involves four GTPases, Rnd1, R-Ras, Rho and Rac1. Sema4D-Plexin-B1 binding promotes Rnd1-dependent activation of the plexin-B1 GAP domain and transient suppression of R-Ras activity. R-Ras inactivation promotes PI3K and Akt inactivation followed by GSK-3beta activation and CRMP2 inactivation. Plexin-B1 also transiently associates with and activates p190Rho-GAP, triggering a transient decrease in activated Rho.
所含基因
8 个基因