Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
中文名称
通路描述
当位于顺式构型时，HD 和 PEST 结构域突变协同作用，使 NOTCH1 转录活性增加约 40 倍，而单独使用 HD 突变可增加约 10 倍，单独使用 PEST 结构域突变可增加约 2 倍（Weng et al. 2004）。HD 结构域突变可引发不依赖配体的自发、蛋白酶解性释放 NICD1 片段，尽管突变体仍对配体结合敏感（Malecki et al. 2006），而 PEST 结构域突变通过干扰 FBXW7（FBW7）介导的泛素化及降解延长 NICD1 半衰期及转录活性（Thompson et al. 2007, O'Neil et al. 2007）。此处标注的 NOTCH1 HD+PEST 结构域突变体包括：NOTCH1 L1600P;P2514Rfs*4、NOTCH1 L1600P;Q2440*、NOTCH1 L1600P;Q2395* 和 NOTCH1 L1574P;P2474Afs*4。
英文描述
Other semaphorin interactions There are eight classes of semaphorins and four types of plexins. Semaphorin (SEMA) classes 1 and 2 are found in invertebrates and classes 3-7 are vertebrate sempahorines. Sempahorin class 3 is secreted, whereas the other classes are synthesised as transmembrane proteins. Vertebrate plexins (PLXNs) are classified into four subfamilies plexin-A to -D. There are four A-type plexins, three B-type, one C-type and D-type. Interactions between different subfamilies of plexins and semaphorins show differential specificity, which trigger different sets of biological functions. Another level of functional specificity specificity is attained by plexins by coupling with various coreceptors expressed in a cell- or tissue-specific manner, such as neuropilins (NRP), L1CAM, c-MET proto-oncogene, ERB2, CD72 and CD45 (Kruger et al. 2005, Law & Lee 2012).
所含基因
19 个基因