DCC介导的趋化信号
中文名称
通路描述
DCC家族包括DCC和neogenin。DCC对于网蛋白诱导的轴突趋化是必需的。DCC是一种缺乏任何可识别催化活性的跨膜蛋白。蛋白酪氨酸激酶2/FAK和Src家族激酶构象持续结合DCC的细胞质末端，其激活与下游细胞内信号复合物耦合，该复合物指导肌动蛋白的组织化。
英文描述
DCC mediated attractive signaling The DCC family includes DCC and neogenin in vertebrates. DCC is required for netrin-induced axon attraction. DCC is a transmembrane protein lacking any identifiable catalytic activity. Protein tyrosine kinase 2/FAK and src family kinases bind constitutively to the cytoplasmic domain of DCC and their activation couples to downstream intracellular signaling complex that directs the organization of actin.
所含基因
15 个基因