网蛋白介导的排斥信号
中文名称
通路描述
Unc5网蛋白受体介导对网蛋白的排斥反应。人类中发现的四个Unc5成员包括Unc5A、B、C和D。不同的研究认为，网蛋白的长距离排斥需要Unc5和DCC的合作，但Unc5单独存在足以介导短距离排斥。网蛋白与Unc5的结合触发Unc5在ZU-5结构域上的磷酸化。一些蛋白质被提出与Unc5家族成员相互作用，以介导排斥反应，包括酪氨酸磷酸酶Shp2、F-肌动蛋白抗帽蛋白Mena和ankyrin。
英文描述
Netrin mediated repulsion signals Unc5 netrin receptors mediate repellent responses to netrin. Four Unc5 members have been found in humans: Unc5A, B, C and D. Different studies have suggested that long-range repulsion to netrin requires the cooperation of Unc5 and DCC, but that Unc5 without DCC is sufficient for short-range repulsion. The binding of netrin to Unc5 triggers the phosphorylation of Unc5 in its ZU-5 domain. Several proteins have been proposed to interact with Unc5 family members in mediating a repellent response, including tyrosine phosphatase Shp2, the F-actin anti-capping protein Mena, and ankyrin.
所含基因
8 个基因