无配体依赖受体介导的 caspase 激活
中文名称
通路描述
在Netrin-1存在下，DCC和UNC5产生吸引和排斥信号以引导生长锥。在Netrin-1缺失的情况下，DCC诱导细胞死亡信号，该信号通过DCC的caspase切割和caspase-9的相互作用启动。最近的研究表明，在Netrin-1缺失的情况下，UNC5受体也能诱导凋亡。这些反应不需要线粒体细胞色素c的释放或与凋亡蛋白酶激活因子1(APAF1)的相互作用。因此，DCC调节了一个不依赖凋亡体(caspase激活)的caspase激活途径。DCC和UNC-5因此被定义为依赖受体。依赖受体在配体可用性的不同下表现出双重功能。它们通过诱导无配体时的细胞依赖状态或配体存在时的细胞凋亡抑制来创建细胞对各自配体的依赖状态。
英文描述
Caspase activation via Dependence Receptors in the absence of ligand In the presence of Netrin1, DCC and UNC5 generate attractive and repulsive signals to growing axons. In the absence of Netrin-1, DCC induces cell death signaling initiated via caspase cleavage of DCC and the interaction of caspase-9. Recent reports have shown that UNC5 receptors similarly induce apoptosis in the absence of Netrin-1. These reactions proceed without a requirement for cytochrome c release from mitochondria or interaction with apoptotic protease activating factor 1 (APAF1). DCC thus regulates an apoptosome-independent pathway for caspase activation. DCC and UNC-5 are hence defined as dependence receptors. Dependence receptors exhibit dual functions depending on the availability of ligand. They create cellular states of dependence on their respective ligands by either inducing apoptosis when unoccupied by the ligand, or inhibiting apoptosis in the presence of the ligand.
所含基因
10 个基因