第二信使在网蛋白-1信号传导中的作用
中文名称
通路描述
如Ca2+、cAMP和cGMP等第二信使的水平可能调节生长锥对特定线索的反应。网蛋白-1作为引导分子依赖于细胞内Ca2+浓度、PI3K和PLCγ的协同激活，以及cAMP的水平。网蛋白首先刺激其受体DCC，导致磷脂酶C的激活。这随后产生信使分子肌醇-1,4,5-三磷酸(IP3)和DAG，后者进而导致细胞内储存的Ca2+释放。Ca2+从储存库的释放然后激活细胞表面的TRPC通道。DAG以直接、膜分隔的方式激活TRPC3和TRPC6，而IP3可能通过耗尽内质网Ca2+水平来激活TRPC通道。
英文描述
Role of second messengers in netrin-1 signaling The levels of second messengers such as Ca+2, cAMP and cGMP may regulate the response of the growth cone to a particular cue. Netrin-1 as a guidance molecule depends on intracellular Ca+2 concentration, coactivation of PI3K and PLCgamma, and the type of response depends on the levels of cAMP. Netrin first stimulates its receptor DCC, resulting in the activation of the enzyme phospholipase C. This then produces the messenger molecules, inositol-1,4,5-trisphosphate (IP3) and DAG, which in turn causes the release of Ca+2 from intracellular stores. Ca+2 release from the stores then activates TRPC channels on the cell surface. DAG activates TRPC3 and TRPC6 in a direct, membrane delimited manner, and IP3 may activate TRPC channels by depleting the ER Ca+2 levels.
所含基因
10 个基因