粘着连接相互作用
中文名称
通路描述
粘着连接(AJ)是多蛋白复合物，通过在离散接触区域连接膜和细胞骨架成分，促进几乎所有组织中同型细胞粘附。粘着连接的分子成分形成粘附单位，组织成更高阶的结缔组织粘附，在相邻细胞之间形成拉链状密封。结缔组织粘附功能在上皮细胞极化和相邻细胞细胞骨架的耦合中起作用，允许协调的运动。在胚胎发育期间，AJ在细胞间粘附中发挥作用，并参与不同细胞类型的排序。AJ还调节细胞极性和形状，促进细胞间通讯，并帮助介导接触抑制。该模块涵盖涉及粘着连接膜蛋白(粘着斑钙粘蛋白和粘着斑神经节苷脂)的二聚化事件(Gumbiner 2005; Ebnet 2008; Hartsock & Nelson 2008)。
英文描述
Adherens junctions interactions The adherens junctions (AJ) are multiprotein complexes that promote homotypic cell adhesion in nearly all types of tissue by linking membrane and cytoskeletal components at discrete contact regions (reviewed in Hartsock & Nelson 2008; Gumbiner 2005; Ebnet, 2008). The molecular constituents of adherens junctions form adhesive units which are organized into higher order junctional adhesions that create a zipper-like seal between adjacent cells. Junctional adhesions function in epithelial cell polarization and in the coupling of cytoskeletons in adjacent cells that allow coordinated movements. During embryonic development, AJs function in specifying adhesion between cells and contribute in the sorting of different cell types. AJs also regulate cell polarity and shape, promote cell-cell communication and help mediate contact inhibition of cell growth. This module covers transdimerization events involving AJ transmembrane proteins (cadherins and nectins) (Gumbiner 2005; Ebnet 2008; Hartsock & Nelson 2008).
所含基因
31 个基因