鞘磷脂和 LPA 受体
中文名称
通路描述
鞘磷脂和 LPA 受体是 G 蛋白偶联受体家族中跨膜蛋白成员，对脂质信号传导至关重要。人类中有八个 LPA 受体，每个由单独基因编码（这些基因有时也称为“端粒分化基因”）。LPA 受体的配体是鞘磷脂外源性信号分子鞘磷脂酰肌醇酸（LPA）和鞘氨醇 1-磷酸（S1P）。主要效应是抑制腺苷酸环化酶并释放内质网中的钙离子，以及次级效应是防止凋亡并增加细胞增殖（Contos JJ 等，2000；An S 等，1998；Fukushima N 和 Chun J，2001）。
英文描述
Lysosphingolipid and LPA receptors The Lysophospholipid receptor (LPLR) group are members of the G protein-coupled receptor family of integral membrane proteins that are important for lipid signaling. In humans there are eight LPL receptors, each encoded by a separate gene (these genes also sometimes referred to as "Edg" or endothelial differentiation gene). The ligands for LPLRs are the lysophospholipid extracellular signaling molecules, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). The primary effects are inhibition of adenylyl cyclase and release of calcium from the endoplasmic reticulum, as well as secondary effects of preventing apoptosis and increasing cell proliferation (Contos JJ et al, 2000; An S et al, 1998; Fukushima N and Chun J, 2001).
所含基因
14 个基因