降钙素样配体受体
中文名称
通路描述
降钙素肽家族包括降钙素、淀粉样蛋白、降钙素基因相关肽（CGRP）、肾上腺髓质素（AM）和间介素（AM2）。降钙素是一种 32 个氨基酸的肽，参与骨稳态（Sexton PM 等，1999）。淀粉样蛋白是胰岛β细胞（Cooper GJ 等，1987）的产物，与胰岛素一起，可能具有调节营养摄入的激素作用（Young A 和 Denaro M，1998）。肾上腺髓质素（AM）是一种普遍表达的肽，最初从肾上腺髓质瘤（一种嗜铬细胞瘤）中分离（Kitamura K 等，1993）。AM 和 AM2（Takei Y 等，2004）属于一种降钙素相关肽激素家族，对调节各种生理功能和体液及组织化学成分至关重要。
这些肽类的受体家族由两类 B 型 GPCRs 组成：降钙素受体（CT）和降钙素受体样受体（CL）（Poyner DR 等，2002）。虽然降钙素受体是传统的 B 型 GPCR，但 CGRP、AM 和淀粉样蛋白的受体需要额外的蛋白质，称为受体活性修饰蛋白（RAMPs）。哺乳动物中有三个 RAMPs；它们与 CT 受体结合，将其转化为对淀粉样蛋白的受体。对于 CGRP 和 AM，相关的 CL 与 RAMP1 结合形成 CGRP 受体，与 RAMP2 或 3 结合形成 AM 受体。CL 本身已知不结合任何内源性配体。
这些肽类的受体家族由两类 B 型 GPCRs 组成：降钙素受体（CT）和降钙素受体样受体（CL）（Poyner DR 等，2002）。虽然降钙素受体是传统的 B 型 GPCR，但 CGRP、AM 和淀粉样蛋白的受体需要额外的蛋白质，称为受体活性修饰蛋白（RAMPs）。哺乳动物中有三个 RAMPs；它们与 CT 受体结合，将其转化为对淀粉样蛋白的受体。对于 CGRP 和 AM，相关的 CL 与 RAMP1 结合形成 CGRP 受体，与 RAMP2 或 3 结合形成 AM 受体。CL 本身已知不结合任何内源性配体。
英文描述
Calcitonin-like ligand receptors The calcitonin peptide family comprises calcitonin, amylin, calcitonin gene-related peptide (CGRP), adrenomedullin (AM) and intermedin (AM2). Calcitonin is a 32 amino acid peptide, involved in bone homeostasis (Sexton PM et al, 1999). Amylin is a product of the islet beta-cell (Cooper GJ et al, 1987), along with insulin and probably has a hormonal role in the regulation of nutrient intake (Young A and Denaro M, 1998). Adrenomedullin (AM) is a ubiquitously expressed peptide initially isolated from phaechromocytoma (a tumour of the adrenal medulla) (Kitamura K et al, 1993). Both AM and AM2 (Takei Y et al, 2004) belong to a family of calcitonin-related peptide hormones important for regulating diverse physiologic functions and the chemical composition of fluids and tissues.
The receptor family for these peptides consists of two class B GPCRs, the calcitonin receptor (CT) and calcitonin receptor-like receptor (CL) (Poyner DR er al, 2002). Whilst the receptor for calcitonin is a conventional class B GPCR, the receptors for CGRP, AM and amylin require additional proteins, called the receptor activity modifying proteins (RAMPs). There are three RAMPs in mammals; they interact with the CT receptor to convert it to receptors for amylin. For CGRP and AM, the related CL interacts with RAMP1 to give a CGRP receptor and RAMP2 or 3 to give AM receptors. CL by itself will bind no known endogenous ligand.
The receptor family for these peptides consists of two class B GPCRs, the calcitonin receptor (CT) and calcitonin receptor-like receptor (CL) (Poyner DR er al, 2002). Whilst the receptor for calcitonin is a conventional class B GPCR, the receptors for CGRP, AM and amylin require additional proteins, called the receptor activity modifying proteins (RAMPs). There are three RAMPs in mammals; they interact with the CT receptor to convert it to receptors for amylin. For CGRP and AM, the related CL interacts with RAMP1 to give a CGRP receptor and RAMP2 or 3 to give AM receptors. CL by itself will bind no known endogenous ligand.
所含基因
10 个基因