碳酸氢盐转运蛋白
中文名称
通路描述
线粒体呼吸氧化产生二氧化碳（CO2）作为废物产物。CO2与碳酸氢盐（HCO3-）处于平衡状态，是机体主要的pH缓冲系统。由于HCO3-带电，无法在未协助的情况下跨膜移动。碳酸氢盐转运蛋白负责将碳酸氢盐跨膜移动。哺乳动物中编码这些转运蛋白的基因共有14个。应用人类基因组组织系统的命名法，碳酸氢盐转运蛋白属于SLC4A和SLC26A家族。在SLC4A家族中，存在两个不同的亚家族，功能上分别对应于电中性Cl-/HCO3-交换子和Na+-耦合的HCO3-共转运子（Romero MF et al, 2004; Cordat E和Casey JR, 2009）。
英文描述
Bicarbonate transporters Respiratory oxidation in the mitochondria produces carbon dioxide (CO2) as a waste product. CO2 is in equilibrium with bicarbonate (HCO3-) and is the body's central pH buffering system. HCO3- is charged so cannot move across membranes unaided. The bicarbonate transport proteins move bicarbonate across the membrane. There are 14 genes which encode these transport proteins in mammals. Applying the Human Genome Organization's sytematic nomenclature to human genes, the bicarbonate transporters belong to the SLC4A and SLC26A families. Within SLC4A, there are two distinct subfamilies, functionally corresponding to the electroneutral Cl-/HCO3- exchangers and Na+-coupled HCO3- co-transporters (Romero MF et al, 2004; Cordat E and Casey JR, 2009).
所含基因
10 个基因