钠/质子交换子
中文名称
通路描述
SLC9基因家族编码蛋白质（钠/质子交换子，NHE或NHX），它们电中性地交换钠离子（内流）和质子（外流）。该机制很重要，因为许多代谢过程产生酸，需要移除以维持pH。这是细胞中主要的质子排出系统，由内钠离子化学梯度驱动。迄今为止，有11个NHE基因，即NHE1-11。NHE1-5在细胞膜上交换阳离子。NHE6-9在内体膜或跨高尔基体网络膜上交换阳离子。
英文描述
Sodium/Proton exchangers The SLC9 gene family encode proteins (sodium/proton exchangers, NHE or NHX) which exchange sodium (influx) for protons (efflux) electroneutrally. This mechanism is important because many metabolic processes generate acids which need to be removed to maintain pH. This is the major proton extruding system in cells, driven by the inward sodium ion chemical gradient. To date, there are eleven NHE genes, NHE1-11. NHE1-5 exchange cations at the cell membrane. NHE6-9 exchange cations at endosomal membranes or the trans-golgi network membranes.
所含基因
9 个基因