返回搜索

Arachidonate production from DAG

Reactome ID: R-HSA-426048

中文名称

从 DAG 合成花生四烯酸

通路描述

花生四烯酸是重要的花生四烯酸来源,是一种信号分子和前列腺素的前体。在人类血小板中,从磷脂酰肌醇降解产生的几乎全部花生四烯酸都来自 DAG(Takamura et al. 1987)。DAG 由 DAG 脂酶水解为 2-花生四烯醇甘油酯(2-AG),后者再由单酰甘油脂酶进一步水解。2-AG 是 cannabinoid 受体 1 的激动剂。
英文描述
Arachidonate production from DAG Diacylglycerol (DAG) is an important source of arachidonic acid, a signalling molecule and the precursor of the prostaglandins. In human platelet almost all the DAG produced from phosphatidylinositol degradation contains arachidonate (Takamura et al. 1987). DAG is hydrolysed by DAG lipase to 2-arachidonylglycerol (2-AG) which is further hydrolysed by monoacylglycerol lipase. 2-AG is an agonist of cannabinoid receptor 1.

所含基因

5 个基因