SIRT1 负调控 rRNA 表达

中文名称

SIRT1 负调控 rRNA 表达

通路描述

rRNA 基因的转录与细胞的整体代谢通过 NAD 依赖性组蛋白去乙酰化酶 SIRT1 耦合，它是能量依赖性的核仁沉默复合体（eNoSC）的组分（Murayama et al. 2008，综述：Salminen and Kaarniranta 2009, Grummt and Voit 2010）。eNoSC 包含核小甲基化酶（NML）、SIRT1 和组蛋白甲基转移酶 SUV39H1（Murayama et al. 2008）。eNoSC 通过 eNoSC 对 rRNA 基因染色质中组蛋白 H3 的脱乙酰化和甲基化导致基因表达降低。当葡萄糖水平低时，NAD 水平高（NADH 水平低），SIRT1 活性高，rRNA 基因活性降低。假设 eNoSC 形成在含有组蛋白 H3 上甲基化赖氨酸 9（H3K9me2）的核小体上，然后 eNoSC 脱乙酰化和甲基化相邻核小体，从而催化 H3K9me2 在整个基因中的扩散。

英文描述

SIRT1 negatively regulates rRNA expression Expression of rRNA genes is coupled to the overall metabolism of the cell by the NAD-dependent histone deacetylase SIRT1, a component of the Energy-dependent Nucleolar Silencing Complex (eNoSC) (Murayama et al. 2008, reviewed in Salminen and Kaarniranta 2009, Grummt and Voit 2010). eNoSC comprises Nucleomethylin (NML), SIRT1, and the histone methylase SUV39H1 (Murayama et al. 2008). Deacetylation and methylation of histone H3 in the chromatin of a rRNA gene by eNoSC causes reduced expression of the gene. When glucose is low, NAD is high (NADH is low), activity of SIRT1 is high, and activity of rRNA genes is reduced. It is hypothesized that eNoSC forms on a nucleosome containing dimethylated lysine-9 on histone H3 (H3K9me2) and then eNoSC deacetylates and dimethylates the adjacent nucleosome, thus catalyzing spreading of H3K9me2 throughout the gene.

所含基因

36 个基因

H2AFB1 H2AFJ H2AFV H2AFX H2BFS H3F3A HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4 HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB RRP8 SIRT1 SUV39H1 TAF1A TAF1B TAF1C TAF1D TBP