CDC42 和 RAC1 的失活
中文名称
通路描述
Rho 家族 GTP 酶，包括 RAC1、RHOA 和 CDC42，是调节轴突引导受体下游细胞骨架动态的理想的候选者。生物化学和遗传学研究揭示了 CDC42 和 RAC1 在 ROBO 排斥中的重要作用。ROBO 通过与 SLIT/ROBO 特异性 GAPs (SrGAPs) 和 Vilse/CrossGAP 相互作用来控制 Rho GTP 酶活性。SrGAPs 特异性地失活 CDC42，Vilse/CrossGAP 特异性地失活 RAC1。最近的研究表明，SRGAP3 可能在 SLIT1 激活的 ROBO2 下游失活 RAC1，这促进了哺乳动物背根 ganglion (DRG) 神经元的轴突生长 (Zhang 等人 2014)。
英文描述
Inactivation of CDC42 and RAC1 Rho family GTPases, including RAC1, RHOA, and CDC42, are ideal candidates to regulate aspects of cytoskeletal dynamics downstream of axon guidance receptors. Biochemical and genetic studies have revealed an important role for CDC42 and RAC1 in ROBO repulsion. ROBO controls the activity of Rho GTPases by interacting with a family of SLIT/ROBO-specific GAPs (SrGAPs) and Vilse/CrossGAP. SrGAPs inactivate CDC42 and Vilse/CrossGAP specifically inactivates RAC1.
It was recently implicated that SRGAP3 may inactivate RAC1 downstream of SLIT1-activated ROBO2, which promotes neurite outgrowth in mammalian dorsal root ganglion (DRG) neurons (Zhang et al. 2014).
It was recently implicated that SRGAP3 may inactivate RAC1 downstream of SLIT1-activated ROBO2, which promotes neurite outgrowth in mammalian dorsal root ganglion (DRG) neurons (Zhang et al. 2014).
所含基因
8 个基因