ABL在ROBO-SLIT信号传导中的作用
中文名称
通路描述
ABL（ABL1或ABL2）在ROBO信号通路中发挥双重作用。作为信号通路中的关键酶促成分，ABL支持排斥信号传导（通过招募必要的肌动蛋白结合蛋白），同时也通过磷酸化下调反馈调节受体，以调整通路的敏感性。ABL与多个效应子协同作用，包括肌动蛋白结合蛋白Capulet（Capt）和Orbit/MAST/CLASP，表明ABL同时协调两种主要细胞骨架系统的动力学，以实现生长锥排斥导向。
英文描述
Role of ABL in ROBO-SLIT signaling ABL (ABL1 or ABL2) plays a dual role in the ROBO pathway. As a key enzymatic component in the signaling pathway, ABL supports repellent signaling (by recruiting the necessary actin binding proteins) and also feeds back on the receptor (by down regulating through phosphorylation) to adjust the sensitivity of the pathway.
ABL cooperates with multiple effectors, including the actin binding protein Capulet (Capt) and Orbit/MAST/CLASP, suggesting that ABL simultaneously coordinates the dynamics of two major cytoskeletal systems to achieve growth cone repellent guidance.
ABL cooperates with multiple effectors, including the actin binding protein Capulet (Capt) and Orbit/MAST/CLASP, suggesting that ABL simultaneously coordinates the dynamics of two major cytoskeletal systems to achieve growth cone repellent guidance.
所含基因
8 个基因