通过TP受体介导的血栓素信号传导
中文名称
通路描述
血栓素（TXA2）结合血栓素受体（TP）。TP有两种剪接变体形式，其胞质羧基末端不同。TPβ首先在血管内皮细胞中被鉴定。TPα在血小板和胎盘中被鉴定。TP的主要信号途径是Gq介导的PLC刺激，导致细胞钙离子增加。TP还与G13耦合，导致Rho和Rac的刺激。
英文描述
Thromboxane signalling through TP receptor Thromboxane (TXA2) binds to the thromboxane receptor (TP). There are 2 splice variant forms of TP, differing in their cytoplasmic carboxyl terminal tails. TP beta was first identified in endothelial cells. TP alpha was identified in platelets and placenta. The major signalling route for TP is Gq-mediated stimulation of PLC and consequent increase in cellular calcium. TP also couples to G13, leading to stimulation of Rho and Rac.
所含基因
24 个基因