mRNA 的无腺苷酸化
中文名称
通路描述
mRNA 的无腺苷酸化分为两步。根据目前的模型，第一步中，PAN2-PAN3 复合物将约 200 个腺苷酸残基缩短为约 80 个残基。第二步中，由 CCR4-NOT 复合物或 PARN 外切酶进一步将 poly(A) 尾缩短为 10-15 个残基。如何使特定的 mRNA 靶向到 CCR4-NOT 或 PARN 尚不清楚。基因组搜索中还可以鉴定出其他多种无腺苷酸化酶。其中特别有趣的是 nocturin，一种与 CCR-1 无腺苷酸化酶相关的蛋白质，在昼夜节律中发挥作用。此外，还有证据表明无腺苷酸化与其他基因表达方面存在网络。例如，CCR4-NOT 已知是一种转录因子。PARN 是调节发育中卵母细胞中 poly(A) 尾长度从而调节翻译的复合物的一部分。
英文描述
Deadenylation of mRNA Deadenylation of mRNA proceeds in two steps. According to current models, in the first step the poly(A) tail is shortened from about 200 adenosine residues to about 80 residues by the PAN2-PAN3 complex. In the second step the poly(A) tail is further shortened to 10-15 residues by either the CCR4-NOT complex or by the PARN exoribonuclease. How a particular mRNA is targeted to CCR4-NOT or PARN is unknown.
A number of other deadenylase enzymes can be identified in genomic searches. One particularly interesting one is nocturin, a protein that is related to the CCR-1 deadenylase and plays a role in circadian rhythms.
There is also evidence for networking between deadenylation and other aspects of gene expression. CCR4-NOT, for example, is known to be a transcription factor. PARN is part of a complex that regulates poly(A) tail length and hence translation in developing oocytes.
A number of other deadenylase enzymes can be identified in genomic searches. One particularly interesting one is nocturin, a protein that is related to the CCR-1 deadenylase and plays a role in circadian rhythms.
There is also evidence for networking between deadenylation and other aspects of gene expression. CCR4-NOT, for example, is known to be a transcription factor. PARN is part of a complex that regulates poly(A) tail length and hence translation in developing oocytes.
所含基因
25 个基因