由 3' 到 5' 外切酶介导的 mRNA 降解
中文名称
通路描述
由 3' 到 5' 外切酶介导的 mRNA 降解分为两步。首先，外切酶外切酶复合物结合寡聚腺苷酸化 mRNA 的 3' 端，并从 3' 到 5' 水解它，产生具有 5'-单磷酸的核糖核苷酸，直到保留一个封头的寡核糖核苷酸。其次，清除性去帽酶 DCPS 水解 7-甲基鸟苷帽。
英文描述
mRNA decay by 3' to 5' exoribonuclease The degradation of mRNA from 3' to 5' occurs in two steps. First, the exosome exoribonuclease complex binds the 3' end of the oligoadenylated mRNA and hydrolyzes it from 3' to 5', yielding ribonucleotides having 5'-monophosphates, until a capped oligoribonucleotide remains. Second, the scavenging decapping enzyme DCPS hydrolyzes the 7-methylguanosine cap.
所含基因
16 个基因