由 5' 到 3' 外切酶介导的 mRNA 降解
中文名称
通路描述
由 5' 到 3' 外切酶介导的 mRNA 降解分为三步。首先，mRNA 由 Lsm1-7 复合物结合在其 3' 端。结合的 Lsm1-7 可能阻止核酸酶接近 3' 端。其次，mRNA 的 7-甲基鸟苷帽由 DCP1-DCP2 复合物水解。第三，5' 端被去帽的 mRNA 攻击的 XRN1 外切酶，从 5' 到 3' 降解 mRNA 的剩余部分。这些过程可能通过 PATL1 物理连接，PATL1 是酵母 Pat1 的同源物，它稳定结合 Lsm1-7 复合物，并与 DCP1-DCP2 去帽复合物和 Ccr4-NOT 无腺苷酸化复合物相互作用 (Ozgur 等，2010)。
英文描述
mRNA decay by 5' to 3' exoribonuclease Degradation of mRNA from 5' to 3' occurs in three steps. First, the mRNA is bound at its 3' end by the Lsm1-7 complex. The bound Lsm1-7 may prevent nucleases from accessing the 3' end. Second, the 7-methylguanosine cap of the mRNA is hydrolyzed by the DCP1-DCP2 complex. Third, the 5' end of the decapped mRNA is attacked by the XRN1 exoribonuclease which digests the remainder of the mRNA from 5' to 3'. These processes may be physically connected by PATL1, the homolog of yeast Pat1, which stably binds the Lsm1-7 complex and interacts with the DCP1-DCP2 decapping complex and the Ccr4-NOT deadenylation complex (Ozgur et al. 2010).
所含基因
15 个基因