甘油通过 Aquaporin 从脂肪细胞运输到肝脏
中文名称
通路描述
脂肪细胞中储存的甘油三酯水解产生脂肪酸和甘油。甘油通过位于脂肪细胞质膜上的 Aquaporin-7 (AQP7) 被动地运输出脂肪细胞并进入血液循环。甘油在血液循环中通过位于肝细胞质膜上的 Aquaporin-9 (AQP9) 被动地运输进入肝细胞。一旦进入肝细胞，甘油是糖异生反应的底物。
英文描述
Transport of glycerol from adipocytes to the liver by Aquaporins Triglycerides stored in adipocytes are hydrolyzed to yield fatty acids and glycerol. The glycerol is passively transported out of the adipocyte and into the bloodstream by Aquaporin-7 (AQP7) located in the plasma membrane of adipocytes. Glycerol in the bloodstream is passively transported into liver cells by AQP9 located in the plasma membrane of hepatocytes. Once inside the liver cell the glycerol is a substrate for gluconeogenesis.
所含基因
2 个基因