血管加压素通过水通道调节肾脏水分稳态
中文名称
通路描述
血管加压素通过水通道调节肾脏水分稳态。在肾脏，水和溶质通过肾小球中nephrin形成的裂隙状结构从血液循环中排出并进入近曲小管。水在近曲小管、降支亨氏袢、远曲小管和集合管中通过滤液被重吸收。近曲小管和降支亨氏袢中的水通道蛋白-1（AQP1）负责约90%的重吸收（基于AQP1小鼠敲除的估计）。AQP1位于上皮细胞的顶面和基底侧表面，因此通过上皮将水转运回血液循环。在集合管上皮细胞中，AQP2位于顶面，AQP3和AQP4位于基底侧表面，以通过上皮转运水。血管加压素通过调节上皮通透性来调节肾脏水分稳态，通过激活信号级联导致AQP2磷酸化和随后从内质网囊泡转位至集合管细胞顶膜。
英文描述
Vasopressin regulates renal water homeostasis via Aquaporins In the kidney water and solutes are passed out of the bloodstream and into the proximal tubule via the slit-like structure formed by nephrin in the glomerulus. Water is reabsorbed from the filtrate during its transit through the proximal tubule, the descending loop of Henle, the distal convoluted tubule, and the collecting duct.
Aquaporin-1 (AQP1) in the proximal tubule and the descending thin limb of Henle is responsible for about 90% of reabsorption (as estimated from mouse knockouts of AQP1). AQP1 is located on both the apical and basolateral surface of epithelial cells and thus transports water through the epithelium and back into the bloodstream.
In the collecting duct epithelial cells have AQP2 on their apical surface and AQP3 and AQP4 on their basolateral surface to transport water across the epithelium. The permeability of the epithelium is regulated by vasopressin, which activates the phosphorylation and subsequent translocation of AQP2 from intracellular vesicles to the plasma membrane.
Aquaporin-1 (AQP1) in the proximal tubule and the descending thin limb of Henle is responsible for about 90% of reabsorption (as estimated from mouse knockouts of AQP1). AQP1 is located on both the apical and basolateral surface of epithelial cells and thus transports water through the epithelium and back into the bloodstream.
In the collecting duct epithelial cells have AQP2 on their apical surface and AQP3 and AQP4 on their basolateral surface to transport water across the epithelium. The permeability of the epithelium is regulated by vasopressin, which activates the phosphorylation and subsequent translocation of AQP2 from intracellular vesicles to the plasma membrane.
所含基因
44 个基因