脂肪酸的细胞内代谢调节胰岛素分泌
中文名称
通路描述
脂肪酸的细胞内代谢调节胰岛素分泌。脂肪酸通过两种机制增强由葡萄糖触发的胰岛素分泌：激活 FFAR1（GPR40）和脂肪酸的细胞内代谢。脂肪酸通过 CD36（FAT）转运进入细胞，并通过与辅酶 A 结合、与辅酶 A 结合、转运到线粒体以及β氧化生成 ATP 进行代谢。ATP 增加了细胞内 ATP:ADP 比率，从而关闭细胞膜上的钾通道（K(ATP) 通道）（综述 Acosta-Montano 和 Garcia-Gonzalez 2018）。代谢脂肪酸的酶在β细胞中也代谢脂肪酸，但它们的组合和亚细胞定位可能不同。
英文描述
Intracellular metabolism of fatty acids regulates insulin secretion Fatty acids augment the glucose triggered secretion of insulin through two mechanisms: activation of FFAR1 (GPR40) and intracellular metabolism of fatty acids. Fatty acids are transported into the cell by CD36 (FAT) (Noushmehr et al. 2005) and metabolized by ligation to coenzyme A (Ansari et al. 2017), transport into mitochondria, and beta oxidation which generates ATP. The ATP increases the intracellular ratio of ATP:ADP and thereby closes potassium channels (K(ATP) channels) at the plasma membrane (reviewed in Acosta-Montano and Garcia-Gonzalez 2018). The enzymes that metabolize fatty acids in beta cells also metabolize fatty acids in other tissues however their combinations and subcellular locations may differ.
所含基因
2 个基因