与 GPR40（FFAR1）结合的脂肪酸调节胰岛素分泌
中文名称
通路描述
与 GPR40（FFAR1）结合的脂肪酸通过两种机制增强由葡萄糖触发的胰岛素分泌：细胞内代谢和激活 FFAR1（GPR40），这是一种 G 蛋白偶联受体。基于 G 蛋白抑制剂（如破伤风毒素）的研究，FFAR1 被认为通过 Gq/11 信号传导。游离脂肪酸与 FFAR1 结合激活异三聚体 Gq 复合物，进而激活磷脂酶 C，产生肌醇 1,4,5-三磷酸，最终导致细胞质内钙离子释放。来自敲除小鼠的实验估计，通过 FFAR1 的信号传导负责约 50% 由游离脂肪酸产生的胰岛素分泌增强。
英文描述
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty acids augment the glucose triggered secretion of insulin through two mechanisms: intracellular metabolism and activation of FFAR1 (GPR40), a G-protein coupled receptor. Based on studies with inhibitors of G proteins such as pertussis toxin FFAR1 is believed to signal through Gq/11. Binding of free fatty acids by FFAR1 activates the heterotrimeric Gq complex which then activates Phospholipase C, producing inositol 1,4,5-trisphosphate and eventually causing the release of intracellular calcium into the cytosol. From experiments in knockout mice it is estimated that signaling through FFAR1 is responsible for about 50% of the augmentation of insulin secretion produced by free fatty acids.
所含基因
8 个基因