NMDA 受体解锁、谷氨酸结合与激活
中文名称
通路描述
在静息膜电位下，NMDA 受体离子通道被细胞外 Mg2+ 离子阻塞，无法在结合配体（谷氨酸、甘氨酸、D-谷氨酸、NMDA）时介导离子渗透。当突触后细胞膜去极化时，Mg2+ 从 NMDA 受体孔（通道）中被排出，导致激活的配体结合 NMDA 受体。膜的去极化可能由 Ca2+ 不可渗透 AMPA 受体的激活引起，这促进了 Na+ 内流，有助于 NMDA 受体的解锁。对于综述，请参见 Traynelis 等人 2010、Paoletti 等人 2013 和 Iacobucci 和 Popescu 2017。
英文描述
Unblocking of NMDA receptors, glutamate binding and activation At resting membrane potential, the NMDA receptor ion channel is blocked by extracellular Mg2+ ions and is unable to mediate ion permeation upon binding of ligands (glutamate, glycine, D-serine, NMDA). The voltage block is removed upon depolarization of the post-synaptic cell membrane and Mg2+ is expelled from the NMDA receptor pore (channel), resulting in activated ligand-bound NMDA receptors. The depolarization of the membrane may happen in response to activation of Ca2+ impermeable AMPA receptors, which facilitates Na+ influx, contributing to the unblocking of NMDA receptors. For review, please refer to Traynelis et al. 2010, Paoletti et al. 2013, and Iacobucci and Popescu 2017.
所含基因
21 个基因