TCF/LEF 与 CTNNB1 结合到靶基因启动子
中文名称
通路描述
由 beta-catenin 和 TCF/LEF 调节的基因涉及细胞增殖、分化、胚胎发生和组织稳态的多种功能，包括转录因子、细胞周期调节因子、生长因子、蛋白酶和炎症细胞因子等（参见 Vlad 等人 2008）。许多 WNT 信号通路组件本身是 TCF/LEF 依赖性转录的阳性或阴性调节靶标，建立反馈回路以增强或限制信号传导（例如，Khan 等人 2007；Chamorro 等人 2005；Roose 等人 1999；Lustig 等人 2002）。除了少数这些通用反馈靶标（如 Axin2）外，大多数靶基因是细胞和组织特异性的。WNT/beta-catenin 依赖性靶基因列表保存在 http://www.standford.edu/group/nusselab/cgi-bin/wnt/target_genes。
英文描述
Binding of TCF/LEF:CTNNB1 to target gene promoters The genes regulated by beta-catenin and TCF/LEF are involved in a diverse range of functions in cellular proliferation, differentiation, embryogenesis and tissue homeostasis, and include transcription factors, cell cycle regulators, growth factors, proteinases and inflammatory cytokines, among others (reviewed in Vlad et al, 2008). A number of WNT signaling components are themselves positively or negatively regulated targets of TCF/LEF-dependent transcription, establishing feedback loops to enhance or restrict signaling (see for instance, Khan et al 2007; Chamorro et al, 2005; Roose et al, 1999; Lustig et al, 2002). Other than a few of these general feedback targets (e.g. Axin2), most target genes are cell- and/or tissue-specific. A list of WNT/beta-catenin-dependent target genes is maintained at http://www.standford.edu/group/nusselab/cgi-bin/wnt/target_genes.
所含基因
8 个基因