雌激素介导的信号通路
中文名称
通路描述
雌激素是一类激素，参与生理过程如发育、生殖、肝脏代谢、脂肪和骨骼代谢，以及神经系统和心血管功能（综述：Aral et al, 2017; Haldosen et al, 2014）。雌激素与雌激素受体结合，后者属于核受体超家族。配体结合的雌激素受体作为核转录因子，调节控制细胞增殖和分化等过程的基因表达，但也发挥非基因组作用，介导从细胞膜快速信号传导（综述：Hah et al, 2014; Schwartz et al, 2016）。
英文描述
Zinc influx into cells by the SLC39 gene family The SLC39 gene family encode zinc transporters belonging to the ZIP (Zrt-, Irt-like proteins) family of metal ion transporters. All ZIPs transport metal ions into the cytoplasm of cells, be it across cellular membranes or from intracellular compartments. To date, there are 14 human SLC39 genes that encode the zinc transporters hZIP1-14. There are 9 members which belong to a subfamily of the ZIPs called the LZTs (LIV-1 subfamily of ZIP zinc transporters) (Taylor KM and Nicholson RI, 2003). Of these 14 proteins, four (hZIP9, 11, 12 and 13) have no function determined yet (Eide DJ, 2004).
所含基因
10 个基因