CREB1 通过 CaMKII/CaMKK/CaMKIV 级联磷酸化
中文名称
通路描述
除了诱导长时程增强 (LTP) 外，NMDA 受体介导的 CaMKII 激活会导致转录变化，这些变化与 LTP 维持有关 (Miyamoto 2006)。CaMKII-γ (CAMK2G) 等位基因参与钙/钙调蛋白复合物 (CALM1:4xCa2+) 的核转运，从而介导 CaMKK 介导的核钙/钙调蛋白依赖性激酶 CaMKIV (CAMK4) 的激活。激活的 CaMKIV 磷酸化转录因子 CREB1 并激活 CREB1 介导的转录 (Ma 等，2014; Cohen 等，2018)。
英文描述
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde In addition to inducing long-term potentiation (LTP), NMDA receptor-mediated activation of CaMKII leads to transcriptional changes that are implicated in LTP maintenance (reviewed by Miyamoto 2006). CaMKII-gamma (CAMK2G) isoform is involved in nuclear shuttling of the calcium/calmodulin complex (CALM1:4xCa2+), which enables CaMKK-mediated activation of the nuclear calcium/calmodulin dependent kinase CaMKIV (CAMK4). Activated CaMKIV phosphorylates the transcription factor CREB1 and activates CREB1-mediated transcription (Ma et al. 2014, Cohen et al. 2018).
所含基因
8 个基因