游离脂肪酸受体
中文名称
通路描述
脂肪酸是游离脂肪酸受体的配体，该受体是一小类 G 蛋白偶联受体的成员，与 GPR120 无关。游离脂肪酸受体 1 (FFAR1/GPR40) 由饱和和不饱和中/长链脂肪酸激活，而 FFAR2 (GPR43) 和 FFAR3 (GPR41) 由短链脂肪酸 (含 6 个或更少碳原子的羧酸盐) 激活。第四个高度同源受体 GPR42 被认为是一个假基因，具有完整的开放阅读框，但在人类人群中可能是一个功能基因。GPR120 由长链 (C16-22) 脂肪酸激活。
英文描述
Free fatty acid receptors Fatty acids are the ligands for a small family of G-protein-coupled receptors, the Free Fatty Acid receptors, and an unrelated receptor GPR120.
Free fatty acid receptor 1 (FFAR1/GPR40) is activated by both saturated and unsaturated medium to long-chain fatty acids while FFAR2 (GPR43) and FFAR3 (GPR41) are activated by short-chain fatty acids (carboxylates) with six or fewer carbon molecules. A fourth highly homologous receptor GPR42 is believed to be a pseudogene with intact open reading frame, but could be a functional gene in a significant fraction of the human population.
GPR120 is activated by long chain (C16-22) fatty acids.
Free fatty acid receptor 1 (FFAR1/GPR40) is activated by both saturated and unsaturated medium to long-chain fatty acids while FFAR2 (GPR43) and FFAR3 (GPR41) are activated by short-chain fatty acids (carboxylates) with six or fewer carbon molecules. A fourth highly homologous receptor GPR42 is believed to be a pseudogene with intact open reading frame, but could be a functional gene in a significant fraction of the human population.
GPR120 is activated by long chain (C16-22) fatty acids.
所含基因
5 个基因