甲酰肽受体结合甲酰肽和其他配体
中文名称
通路描述
甲酰肽受体（FPR）在1976年被药理学定义为中性粒细胞表面对肽N-甲酰-甲硫氨酸-亮氨酸-苯丙氨酸（fMLF）的高亲和力结合位点。FPR于1990年被克隆，该cDNA用作探针以鉴定两个额外的基因FPRL1和FPRL2。这三个基因位于19q13.3簇上。所有基因都与Gi家族G蛋白偶联。所有3种受体均可被甲酰肽激活，但也对一系列结构多样的配体表现出亲和力。
英文描述
Formyl peptide receptors bind formyl peptides and many other ligands The formyl peptide receptor (FPR) was defined pharmacologically in 1976 as a high affinity binding site on the surface of neutrophils for the peptide N-formyl-methionine-leucine-phenylalanine (fMLF). FPR was cloned in 1990 and the cDNA used as a probe to identify two additional genes, FPRL1 and FPRL2. The three genes for a cluster on 19q13.3. All are coupled to the Gi family of G proteins.
All 3 receptors can be activated by formyl peptides but also display affinities for a range of structurally diverse ligands.
All 3 receptors can be activated by formyl peptides but also display affinities for a range of structurally diverse ligands.
所含基因
8 个基因