松弛素受体
中文名称
通路描述
松弛素是胰岛素在早期脊椎动物进化中分化的肽激素家族的一部分，形成了胰岛素样肽和松弛素，现在通常被称为松弛素肽家族。所有都是异二聚体；两条链都从共同的前肽中切割，并通过2个二硫键交联。人类有3种真正的松弛素，由3个相关基因编码，此外还有几个更远的胰岛素样肽基因。非灵长类动物有2种松弛素基因。人类循环中的主要松弛素形式是松弛素-2，相当于非灵长类动物中的松弛素-1。松弛素-3高度保守。关于人类松弛素-1知之甚少；许多胰岛素样肽已知没有受体或功能。有4种人松弛素家族肽的G蛋白偶联受体。松弛素受体1（RXFP1）和松弛素受体2（RXFP2）分别被称为LGR7和LGR8，它们是含有LRR的G蛋白偶联受体（LGRs）成员。松弛素-3受体1（RXFP3）和松弛素-3受体2（RXFP4）不相关，与类似小肽受体（如瘦素受体）的异质性更高。
英文描述
Relaxin receptors Relaxins are part of a family of peptide hormones that diverged from insulin in early vertebrate evolution to form the insulin-like peptides and relaxins, now often referred to as the relaxin peptide family. All are heterodimers; both chains are cleaved from a common propeptide and cross-linked by 2 disulphide bonds. Humans have 3 true relaxins encoded by 3 related genes, plus several more distantly related insulin-like peptide genes. Non-primates have 2 relaxin genes. The major circulating form of relaxin in humans is relaxin-2, equivalent to relaxin-1 in non-primates. Relaxin-3 is very highly conserved. Little is known about human relaxin-1; several of the insulin-like peptides have no known receptor or function.
There are 4 human G-protein coupled receptors for relaxin family peptides. Relaxin receptor 1 (RXFP1) and relaxin receptor 2 (RXFP2) are also known as LGR7 and LGR8 respectively, members of the LRR-containing G protein-coupled receptors (LGRs). Relaxin-3 receptor 1 (RXFP3) and Relaxin-3 receptor 2 (RXFP4) are unrelated, having more homology with small peptide receptors such as the somatostatin receptors.
There are 4 human G-protein coupled receptors for relaxin family peptides. Relaxin receptor 1 (RXFP1) and relaxin receptor 2 (RXFP2) are also known as LGR7 and LGR8 respectively, members of the LRR-containing G protein-coupled receptors (LGRs). Relaxin-3 receptor 1 (RXFP3) and Relaxin-3 receptor 2 (RXFP4) are unrelated, having more homology with small peptide receptors such as the somatostatin receptors.
所含基因
8 个基因