L1与锚蛋白相互作用
中文名称
通路描述
锚蛋白是一类将膜蛋白（如电压门控Na+通道和Na+/K+离子交换体）耦合到肌动蛋白细胞骨架的适配器蛋白。锚蛋白由三个基因（ankyrin-G、-B和-R）编码，其中ankyrin-G和-B是发育中神经系统表达的主要形式。锚蛋白结合L1CAM胞内区并耦合它们和离子通道蛋白到肌动蛋白细胞骨架。这种结合增强了L1的同源粘附活性并减少了其在细胞膜内的移动性。L1与锚蛋白的相互作用介导了皮质抑制性神经元的分支和突触发生。
英文描述
Interaction between L1 and Ankyrins Ankyrins are a family of adaptor proteins that couple membrane proteins such as voltage gated Na+ channels and the Na+/K+ anion exchanger to the spectrin actin cytoskeleton. Ankyrins are encoded by three genes (ankyrin-G, -B and -R) of which ankyrin-G and -B are the major forms expressed in the developing nervous system. Ankyrins bind to the cytoplasmic domain of L1 CAMs and couple them and ion channel proteins, to the spectrin cytoskeleton. This binding enhances the homophilic adhesive activity of L1 and reduces its mobility within the plasma membrane. L1 interaction with ankyrin mediates branching and synaptogenesis of cortical inhibitory neurons.
所含基因
31 个基因