L1信号转导
中文名称
通路描述
除了细胞间粘附作用外，L1作为信号转导受体发挥作用，为神经元提供来自环境的线索，以指导轴突生长和导向。L1与细胞表面β1整合素结合，诱导涉及pp60csrc、Vav2-GEF、Rac1、PAK1、MEK和ERK1/2级联激活的信号通路。L1通过MAP激酶ERK1/2刺激细胞迁移和树突生长。CHL1也与整合素结合，通过pp60c-src、MEK和ERK1/2激活MAPK信号通路。L1还结合Sema3A受体神经皮层素1，作为必需核心受体介导Sema3A诱导的生长锥塌陷和轴突排斥。这种排斥可以通过L1在相邻细胞上的同源结合转化为吸引，在响应神经元中，L1与神经皮层素1（NP1）复合物结合。L1还与FGF受体结合，激活PLCγ和DAG，导致花生四烯酸产生和电压门控通道开放。
英文描述
Signal transduction by L1 Besides adhesive roles in cell cell interaction, L1 functions as a signal transducing receptor providing neurons with cues from their environment for axonal growth and guidance. L1 associates with beta1 integrins on the cell surface to induce a signaling pathway involving sequential activation of pp60csrc, Vav2 -GEF, Rac1, PAK1, MEK and ERK1/2. L1 stimulates cell migration and neurite outgrowth through the MAP kinases ERK1/2. CHL1 also associates with integrins and activates a MAPK signaling pathway via pp60c-src, MEK and ERK1/2.
L1 also binds the Sema3A receptor neuropilin1 and acts as an obligate coreceptor to mediate Sema3A induced growth cone collapse and axon repulsion. This repulsion can be converted to attraction by homophilic binding of L1 on an apposing cell in trans with L1 complexed with Neuropilin1 (NP1) in the responding neuron.
L1 also interacts with FGF receptor and activates PLC gamma and DAG, resulting in the production of arachidonic acid and subsequent opening of voltage-gated channels.
L1 also binds the Sema3A receptor neuropilin1 and acts as an obligate coreceptor to mediate Sema3A induced growth cone collapse and axon repulsion. This repulsion can be converted to attraction by homophilic binding of L1 on an apposing cell in trans with L1 complexed with Neuropilin1 (NP1) in the responding neuron.
L1 also interacts with FGF receptor and activates PLC gamma and DAG, resulting in the production of arachidonic acid and subsequent opening of voltage-gated channels.
所含基因
20 个基因