NrCAM 相互作用
中文名称
通路描述
NrCAM 是 L1 家族细胞粘附分子的一员，参与神经节发育和郎飞结形成。与 L1 家族所有其他成员一样，NrCAM 也能结合锚蛋白。NrCAM 的 C 末端氨基酸形成 PDZ 结合基序，可与 SAP102 和 SAP97 相互作用。GPI 锚定的 TAG-1/axonin-1 成员已被证明可与 NrCAM 相互作用。NrCAM 还结合 Sema3B 受体 NP-2 以介导排斥性的轴突导向。
英文描述
NrCAM interactions The NgCAM-related cell adhesion molecule (NrCAM) is member of the L1 family involved in the eye development and node of Ranvier. Like all the other members of L1 family NrCAM also has the ability to bind to ankyrins. The last C-terminal amino acids of NrCAM form a PDZ-binding motif and can interact with SAP (synapse-associated protein) 102 and SAP97. Member of the GPI-anchored TAG-1/axonin-1 have been shown to interact with NrCAM. NrCAM also binds the Sema3B receptor NP-2 to mediate repulsive axon guidance.
所含基因
7 个基因