CHL1 相互作用
中文名称
通路描述
CHL1 是 L1 家族细胞粘附分子的一员，由中枢和周围神经系统中的亚群神经元和胶质细胞表达。CHL1 像 L1 一样促进神经元存活和轴突生长。CHL1 具有 L1 家族成员的基本结构排列，但与所有成员不同，它不能形成同型粘附。CHL1 的第二 Ig 样结构域包含整合素相互作用基序 RGD，而不是像 L1 那样在第六个 Ig 样结构域中，但 CHL1 的第六个 Ig 样结构域具有另一个潜在的整合素结合基序 DGEA。CHL1 通过 Ig1 序列 FASNRL 结合 NP-1 以介导排斥性的轴突导向至 Sema3A。CHL1 是 L1 家族中唯一在锚蛋白结合域中序列改变（FIGAY）的成员，并且缺乏其他 L1 家族成员特征的分选/内吞 RSLE 基序。
英文描述
CHL1 interactions Close homolog of L1 (CHL1) is a member of the L1 family of cell adhesion molecules expressed by subpopulations of neurons and glia in the central and peripheral nervous system. CHL1 like L1 promotes neuron survival and neurite outgrowth. CHL1 shares the basic structural arrangement of L1 family members yet in contrast to all the members it is not capable of forming homophilic adhesion. The second Ig-like domain of CHL1 contains the integrin interaction motif RGD rather than with in the sixth Ig-like domain as in L1, however the sixth Ig-like domain of CHL1 has another potential integrin binding motif DGEA. CHL1 binds NP-1 via the Ig1 sequence FASNRL to mdediate repulsive axon guidance to Sema3A. CHL1 is the only L1 family member with an altered sequence (FIGAY) in the ankyrin-binding domain, and it lacks the sorting/endocytosis RSLE motif, which is characteristic of other L1 family members.
所含基因
9 个基因