神经节钙粘蛋白相互作用
中文名称
通路描述
神经节钙粘蛋白是一种 L1 家族免疫球蛋白细胞粘附分子，参与神经发育过程中的轴突亚细胞定位和突触形成。在神经节钙粘蛋白中已鉴定出多种不同的异构体，其中两种被广泛研究，即 186kDa 的通常称为神经元形式的，存在于郎飞结神经元中，以及 155kDa 的称为胶质形式的，存在于施万细胞中。神经节钙粘蛋白与 NrCAM 和锚蛋白 G 共定位于郎飞结。神经节钙粘蛋白与 NrCAM 进行异型粘附，并刺激鸡脑桥延髓神经元的轴突生长。神经节钙粘蛋白的最后一个几个氨基酸形成 PDZ 类 I 结合基序（SLA），并通过这些最后一个几个氨基酸与 syntenin-1 结合。
英文描述
Neurofascin interactions Neurofascin is an L1 family immunoglobulin cell adhesion molecule involved in axon subcellular targeting and synapse formation during neural development. There are a range of different isoforms identified in Neurofascin of which two of them are well studied the 186kDa commonly referred to as neuronal form and is present in node of Ranvier neurons and the 155kDa form known as a glial form present in schwann cells.
Neurofascin colocalizes with NrCAM and ankyrinG at the nodes of Ranvier. Neurofascin participates in transheterophilic adhesion with NrCAM and stimulates neurite outgrowth in chicken tectal neurons. The last few amino acids of neurofascin form the PDZ class I binding motif (SLA) and through these last few amino acids it associates with syntenin-1.
Neurofascin colocalizes with NrCAM and ankyrinG at the nodes of Ranvier. Neurofascin participates in transheterophilic adhesion with NrCAM and stimulates neurite outgrowth in chicken tectal neurons. The last few amino acids of neurofascin form the PDZ class I binding motif (SLA) and through these last few amino acids it associates with syntenin-1.
所含基因
7 个基因