HuR (ELAVL1)
中文名称
通路描述
HuR (ELAVL1) 是一种普遍存在的蛋白质，结合 mRNA 中的 AU 富集元件，并稳定 mRNA。HuR 活性受磷酸化控制，PKC alpha 和 PCK delta 增强 HuR 结合和稳定 mRNA 的能力。mRNA 的结合发生在细胞核内，然后 HuR 与 CRM1 出口途径相互作用，将 mRNA 转移到细胞质。HuR 保护 mRNA 免受降解的机制尚不清楚。HuR 还调节某些 mRNA 的翻译，在某些情况下抑制翻译，在某些情况下通过招募 mRNA 到多聚核糖体增强其翻译。HuR 结合并调节编码环氧化酶 -2 (COX2, PTGS2)、 Cyclin A (CCNA, CCNA2)、 Cyclin D1 (CCND1)、 Cyclin B1 (CCNB1)、CD83 抗原 (CD83) 和原癌基因 c-Fos (FOS) 的 mRNA。HuR 是 HuD (ELAVL4)、HuB (ELAVL2) 和 HuC (ELAVL3) 家族蛋白的一员。HuB、HuC 和 HuD 在神经组织中特异性表达。HuR 参与凋亡。在致死性应激下，HuR 大部分进入细胞质，是 Caspase-3 和 Caspase-7 的靶标。HuR 的切割产物反过来促进凋亡。
英文描述
HuR (ELAVL1) binds and stabilizes mRNA HuR (ELAVL1) is a ubiquitous protein that binds AU-rich elements in mRNAs and acts to stabilize the mRNAs. HuR activity is controlled by phosphorylation, with PKC alpha and PCK delta enhancing the ability of HuR to bind and stabilize mRNAs. Binding of mRNAs occurs in the nucleus and HuR then interacts with the CRM1 export pathway to transfer the mRNA to the cytoplasm. The mechanism by which HuR shields the mRNA from degradation is unknown.
HuR also regulates translation of some mRNAs, in some cases repressing translation and in some cases enhancing translation of bound mRNAs by recruiting them to polysomes.
HuR binds and regulates mRNAs encoding Cyclooxygenase-2 (COX2, PTGS2), Cyclin A (CCNA, CCNA2), Cyclin D1 (CCND1), Cyclin B1 (CCNB1), CD83 antigen (CD83), and proto-oncogene c-Fos (FOS).
HuR is a member of a family of proteins that also contains HuD (ELAVL4), HuB (ELAVL2), and HuC (ELAVL3). HuB, HuC, and HuD are specifically expressed in neural tissue.
HuR participates in apoptosis. During lethal stress HuR becomes mostly cytoplasmic and is a target of Caspase-3 and Caspase-7. The cleavage products of HuR in turn promote apoptosis.
HuR also regulates translation of some mRNAs, in some cases repressing translation and in some cases enhancing translation of bound mRNAs by recruiting them to polysomes.
HuR binds and regulates mRNAs encoding Cyclooxygenase-2 (COX2, PTGS2), Cyclin A (CCNA, CCNA2), Cyclin D1 (CCND1), Cyclin B1 (CCNB1), CD83 antigen (CD83), and proto-oncogene c-Fos (FOS).
HuR is a member of a family of proteins that also contains HuD (ELAVL4), HuB (ELAVL2), and HuC (ELAVL3). HuB, HuC, and HuD are specifically expressed in neural tissue.
HuR participates in apoptosis. During lethal stress HuR becomes mostly cytoplasmic and is a target of Caspase-3 and Caspase-7. The cleavage products of HuR in turn promote apoptosis.
所含基因
8 个基因