KSRP (KHSRP)
中文名称
通路描述
KSRP (KHSRP) 结合 mRNA 3'非翻译区中的 AU 富集序列。KSRP 通过招募外切酶和脱帽酶使结合的 mRNA 靶向水解。KSRP 的活性受磷酸化调节。蛋白激酶 B/Akt 在 KSRP 的第 193 位丝氨酸上磷酸化。磷酸化抑制 KSRP 破坏 mRNA 的能力。KSRP 在磷酸化后结合 14-3-3zeta (YWHAZ)，导致 KSRP 被保留在细胞核内。
英文描述
KSRP (KHSRP) binds and destabilizes mRNA KSRP binds to AU-rich sequences in the 3' untranslated regions of mRNAs. KSRP causes the bound mRNA to be targeted for hydrolysis by recruiting exonucleases and decapping enzymes. The activity of KSRP is regulated by phosphorylation. Protein kinase B/Akt phosphorylates KSRP at serine193. The phosphorylation inhibits the ability of KSRP to destabilize mRNA. KSRP phosphorylated at serine193 binds 14-3-3zeta (YWHAZ) which causes KSRP to be retained in the nucleus.
所含基因
18 个基因