DNA 复制蛋白的 SUMO 化
中文名称
通路描述
滑动夹蛋白 PCNA、Aurora-A、Aurora-B、Borealin 以及各种拓扑异构酶可以被 SUMO 化（综述 Wan 等人，2012）。PCNA 的 SUMO 化似乎减少了双链断裂的形成和不适当的重组（综述 Watts 2006, Watts 2007, Dieckman 等人，2012, Gazy 和 Kupiec 2012）。Aurora-A、Aurora-B 和 Borealin 的 SUMO 化对于正确的染色体分离是必需的。拓扑异构酶的 SUMO 化是在拓扑异构酶抑制剂造成的损伤后观察到的。
英文描述
SUMOylation of DNA replication proteins The sliding clamp protein PCNA, Aurora-A, Aurora-B, Borealin, and various topoisomerases can be SUMOylated (reviewed in Wan et al. 2012). SUMOylation of PCNA appears to reduce formation of double-strand breaks and inappropriate recombination (reviewed in Watts 2006, Watts 2007, Dieckman et al. 2012, Gazy and Kupiec 2012). SUMOylation of Aurora-A, Aurora-B, and Borealin is necessary for proper chromosome segregation. SUMOylation of topoisomerases is observed in response to damage caused by inhibitors of topoisomerases.
所含基因
45 个基因
AAAS
AURKA
AURKB
BIRC5
CDCA8
INCENP
NDC1
NUP107
NUP133
NUP153
NUP155
NUP160
NUP188
NUP205
NUP210
NUP214
NUP35
NUP37
NUP43
NUP50
NUP54
NUP62
NUP85
NUP88
NUP93
NUPL2
PCNA
PIAS3
PIAS4
POM121
POM121C
RAE1
RANBP2
SEC13
SUMO1-C93-UBE2I
SUMO2-C93-UBE2I
SUMO3-C93-UBE2I
TOP1
TOP2A
TOP2B
TPR
UBE2I
UBE2I-G92-SUMO3
UBE2I-G93-SUMO2
UBE2I-G97-SUMO1