免疫反应蛋白的 SUMO 化
中文名称
通路描述
NF-κB 转录因子由于与 IkappaB 结合而被限制在细胞质中。在 NF-κB 激活期间，IKK 磷酸化 IkappaB，释放 NF-κB 以便导入细胞核。NF-κB 转录因子、IkappaB 的 NFKBIA 组分和 IKK 复合物的亚基可被 SUMO 化（综述 Kracklauer 和 Schmidt 2003, Liu 等 2013）。IkappaB、NFKBIA 和 RELA 的 SUMO 化抑制 NF-κB 信号传导；NFKB2 的 SUMO 化对于蛋白水解加工是必需的。
英文描述
SUMOylation of immune response proteins NF-kappaB transcription factors are sequestered in the cytosol due to their association with IkappaB. During activation of NF-kappaB, IKK phosphorylates IkappaB, releasing NF-kappaB for importation into the nucleus. NF-kappaB transcription factors, the NFKBIA component of IkappaB, and subunits of the IKK complex can be SUMOylated (reviewed in Kracklauer and Schmidt 2003, Liu et al. 2013). SUMOylations of IkappaB, NFKBIA, and RELA inhibit NF-kappaB signaling; SUMOylation of NFKB2 is required for proteolytic processing.
所含基因
16 个基因