谷氨酸受体突触前功能
中文名称
通路描述
谷氨酸受体突触前神经元中的谷氨酸受体参与调节谷氨酸和γ-氨基丁酸（GABA）等神经递质的释放。谷氨酸受体的这种活性与通道中的离子流无关。含有GRIK3的同源谷氨酸受体被证明参与此过程。谷氨酸受体在这些神经元中结合G蛋白偶联受体，激活磷脂酶C，最终触发从细胞内储存中释放的Ca2+。释放的Ca2+进一步引发突触囊泡的融合和释放，释放神经递质。
英文描述
Presynaptic function of Kainate receptors Kainate receptors in the presynaptic neuron are involved in modulating the release of neurotransmitters like glutamate and gamma amino butyric acid (GABA). This activity of Kainate receptors is independent of ionic fluxes through the channel. Homomeric kainate receptors containing GRIK3 are shown to be involved in this process. Kainate receptors in these neurons bind G-protein coupled receptors that activate phospholipase C which eventually triggers the release of Ca2+ from the intracellular stores. The released Ca2+ further initiates the fusion and release of vesicles containing the neurotransmitter.
所含基因
21 个基因