B-WICH 复合物正调控 rRNA 表达

中文名称

通路描述

B-WICH 复合物是一个包含 SMARCA5 (SNF2H)、BAZ1B (WSTF)、ERCC6 (CSB)、MYO1C (核肌球蛋白 1c)、SF3B1、DEK、MYBBP1A 和 DDX21 (Cavellan 等人 2006, Percipalle 等人 2006, Vintermist 等人 2001, Sarshad 等人 2013, Shen 等人 2013, 综述 Percipalle 和 Farrants 2006) 的大型 300 kDa 复合物。B-WICH 复合物存在于活跃的 rRNA 基因位点以及 5S rRNA 和 7SL RNA 基因位点。B-WICH 似乎能重塑染色质并招募组蛋白乙酰转移酶，将组蛋白修饰至转录活跃状态。

英文描述

B-WICH complex positively regulates rRNA expression The B-WICH complex is a large 3 Mdalton complex containing SMARCA5 (SNF2H), BAZ1B (WSTF), ERCC6 (CSB), MYO1C (Nuclear myosin 1c), SF3B1, DEK, MYBBP1A, and DDX21 (Cavellan et al. 2006, Percipalle et al. 2006, Vintermist et al. 2001, Sarshad et al. 2013, Shen et al. 2013, reviewed in Percipalle and Farrants 2006). B-WICH is found at active rRNA genes as well as at 5S rRNA and 7SL RNA genes. B-WICH appears to remodel chromatin and recruit histone acetyltransferases that modify histones to transcriptionally active states.

所含基因

58 个基因

ACTB BAZ1B CD3EAP DDX21 DEK EP300 ERCC6 GSK3B H2AFB1 H2AFJ H2AFV H2AFX H2BFS H3F3A HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AJ HIST1H2BA HIST1H2BB HIST1H2BC HIST1H2BD HIST1H2BH HIST1H2BJ HIST1H2BK HIST1H2BL HIST1H2BM HIST1H2BN HIST1H2BO HIST1H3A HIST1H4 HIST2H2AA3 HIST2H2AC HIST2H2BE HIST2H3A HIST3H2BB KAT2A KAT2B MYBBP1A POLR1A POLR1B POLR1C POLR1D POLR1E POLR2E POLR2F POLR2H POLR2K POLR2L SF3B1 SMARCA5 TAF1A TAF1B TAF1C TAF1D TBP TWISTNB ZNRD1