肉毒杆菌毒素 D 的毒性
中文名称
通路描述
肉毒杆菌毒素 D (botD) 仅与人类疾病极少相关 (Hatheway 1995)，且尚未描述其从人类肠道进入循环的途径。尽管如此，该毒素本身是一种二硫键连接的轻链 (LC) - 重链 (HC) 异二聚体 (称为“双链”)，能通过细胞表面糖脂 (Kroken 等人 2011) 和突触囊泡蛋白 2 (SV2) (Peng 等人 2011) 与神经元相互作用。结合毒素可进入突触囊泡并释放其 LC 部分进入靶细胞胞质 (Montal 2010)，而 botD LC 可切割突触囊泡膜蛋白 1 和 2 (VAMP1 和 2) 的胞质面 (Schiavo 等人 1993; Yamasaki 等人 1994)。此处注释了上述四个事件。
英文描述
Toxicity of botulinum toxin type D (botD) Botulinum toxin type D (botD) is only very rarely associated with human disease (Hatheway 1995) and a pathway by which it might enter the circulation from the human gut has not been described. Nevertheless, the toxin itself, a disulfide-bonded heavy chain (HC) - light chain (LC) heterodimer (âdichainâ), is capable of binding to neurons by interactions with cell surface ganglioside (Kroken et al. 2011) and synaptic vesicle protein 2 (SV2) (Peng et al. 2011), the bound toxin can enter synaptic vesicles and release its LC moiety into the cytosol of targeted cells (Montal 2010), and the botD LC can cleave vesicle associated membrane proteins 1 and 2 (VAMP1 and 2) on the cytosolic face of the synaptic vesicle membrane (Schiavo et al. 1993; Yamasaki et al. 1994). These four events are annotated here.
所含基因
5 个基因