破伤风毒素的毒性
中文名称
通路描述
破伤风毒素 (tetX，也称为 TeNT) 是一种二硫键连接的轻链 (LC) - 重链 (HC) 二聚体，由感染伤口中的细菌直接分泌至循环中。循环毒素分子与靶神经元的突触糖脂结合。毒素被内吞到氯仿包被囊泡中，通过逆行运输到达神经元细胞体，然后可能通过其他神经元，随后发生酸化。囊泡酸化导致毒素发生构象变化，使其 HC 部分作为通道，其 LC 部分被挤出至神经元胞质中。HC - LC 二硫键的切割释放 LC 进入胞质，其中它作为锌金属蛋白酶切割囊泡相关膜蛋白 2 (VAMP2)，从而阻断突触囊泡外泌 (Lalli et al. 2003)。
英文描述
Toxicity of tetanus toxin (tetX) Tetanus toxin (tetX, also known as TeNT), a disulfide-bonded heavy chain (HC) - light chain (LC) dimer, is secreted from bacteria growing in an infected wound directly into the circulation. Circulating toxin molecules associate with gangliosides at a synapse of a target neuron. The toxin is taken up into clathrin-coated vesicles that reach the neuron cell body by retrograde transport and then possibly other neurons before undergoing acidification. Vesicle acidification causes a conformational change in the toxin, allowing its HC part to function as a channel through which its LC part is extruded into the neuronal cytosol. Cleavage of the HC - LC disulfide bond releases the LC into the cytosol, where it functions as a zinc metalloprotease to cleave vesicle-associated membrane protein 2 (VAMP2), thereby blocking synaptic vesicle exocytosis (Lalli et al. 2003).
所含基因
1 个基因