TCF7L2 突变体的信号传导
中文名称
通路描述
~50% 带有微卫星不稳定的结肠癌显示 TCF7L2 的移码突变，导致 CTBP 结合区丧失 (Duval et al, 1999; Cuilliere-Dartigues et al, 2006)。这些癌细胞显示 CTBP 和 TCF7L2 共定位降低，并表现出 TCF 依赖性报告基因的升高表达 (Cuilliere-Dartigues et al, 2006)。
英文描述
Signaling by TCF7L2 mutants ~50% of colorectal cancers with microsatellite instability show frameshift mutations in TCF7L2 that result in the loss of the CTBP-binding region (Duval et al, 1999; Cuillliere-Dartigues et al, 2006). These cancer cells show decreased colocalization of CTBP and TCF7L2 and have increased expression of a TCF-dependent reporter gene (Cuilliere-Dartigues et al, 2006).
所含基因
2 个基因